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KMID : 0644120040170010029
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Journal of Oriental Gynecology
2004 Volume.17 No. 1 p.29 ~ p.42
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The work of Silsosan on growth of uterine myomal cells, MAP kinase activity, and Cell Apoptosis
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Baek Seung-Hee
Kim Dong-Chul
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Abstract
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Purpose :These experiments were carried out to examine the effect of inhibitory effect of Silsosan on the growth of human uterine myomal cells in vitro
Methods :(1) The control was uterine myomal cells cultured in optimum conditions and experimental samples were cultured in optimum conditions plus the addition of these concentrations of Silsosan: 10, 5, 1, 0.5, 0.1, 0.05 and 0.01 percent. (2) MAP kinase and bcl-2 gene were compared in in vitro cultured uterine myomal cells between control and treatment groups.
Results :Any concentration of Silsosan above 5% yielded growth inhibition. demonstrating the effectiveness of Silsosan as a growth inhibitor on uterine myomal cells. The MAP kinase activity in uterine myomal cells treated with Silsosan was decreased to the concentration of 0.1% yielded and the expression of bcl-2, a Cell Apoptosis-related gene, in uterine myoma cells treated with Silsosan was gradually increased with increasing concentration of Silsosan.
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KEYWORD
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Silsosan, uterine myomal cells, MAP kinase, bcl-2
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